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. 2021 Jun 13;19:181. doi: 10.1186/s12951-021-00932-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Therapeutic efficacy of BBPQDs in vitro. a Cell viability of HBL-100 cells treated with BPQDs and BBPQDs. b Cell viability of 4T1 cells treated with BPQDs and BBPQDs. c Cell viability of 4T1 cells treated with NIR, BPQDs + NIR, and BBPQDs + NIR (808 nm, 1.0 W/cm², 5 min). d Flow cytometric analysis of 4T1 cells apoptosis induced by different formulations under irradiation (808 nm, 1.0 W/cm², 5 min) or not using Annexin V-FITC PI staining. e Corresponding percentages of early apoptotic and late apoptotic tumor cells after different treatments using flow cytometry analysis