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. 2021 Jun 13;21:311. doi: 10.1186/s12935-021-02011-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effects of exosomes from MM patients on H9C2 cells. A The level of circ-G042080 was significantly increased in the exosome group (P < 0.01). After blocking the exosomes with GW4869, the level of circ-G042080 decreased. B The level of hsa-miR-4268 was significantly increased in the exosome group (P < 0.01) and then decreased after blocking exosomes with GW4869. C, A The level of TLR4 was significantly increased in the exosome group (P < 0.01) and then decreased after blocking exosomes with GW4869. D CCK-8 assay results showed that the proliferation rate of H9C2 cells in the exosome group was significantly reduced (P < 0.01) and that the cell proliferation rate increased after the exosomes were blocked with GW4869. E The level of LC3 was significantly increased in the exosome group (P < 0.01) and then decreased after blocking exosomes with GW4869. F WB results showed increased LC3-II/I and Beclin1 levels and a decreased P62 level in the exosome group compared with the control group. G Immunofluorescence results showing the LC3 expression level in H9C2 cells. H Compared with that in the control group, the LC3 expression level in the exosome group was significantly increased (P < 0.01). I Observation of the number of autophagic vesicles in H9C2 cells via electron microscopy. The red marks from left to right indicate mitochondria, autophagic vesicles, autophagic lysosomes, mitochondria, and mitochondria. J The results showed easily visible autophagic vacuoles in the exosome group, and the number was obviously greater than that in the control group