Fig. 6.

Model for MutLγ mechanism in meiotic recombination. In meiotic recombination, MutLγ, in complex with Exo1, is recruited by MutSγ on dHJ intermediates (A–B). Transient MutLγ polymerization is proposed to occur at this step leading to an incision of the DNA away from the dHJ (C). This polymerization is proposed to involve three patches including the MIP-binding site of Mlh1. Further studies should help to evaluate whether competition exists between Exo1 and Mlh3 for the Mlh1 MIP-binding site.