Fig. 2.

BH3 profiling reveals differential priming at baseline and during p53 reactivation. (A) Baseline mitochondrial priming profiles of sarcoma, lung adenocarcinoma, and lymphoma cell lines showing increased priming in lymphoma relative to all other cell lines. Three independent samples were tested for each tumor type. (B) Comparison of priming measured by BIM peptide at 0.75 μM showing the difference between lymphoma priming and all other cell lines. ****P < 0.0001; n.s., not significant. (C and D) BH3 profiling showing increase in priming with time after p53 restoration in lung adenocarcinoma and sarcoma cell lines, respectively.