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. 2021 May 31;118(23):e2019740118. doi: 10.1073/pnas.2019740118

Fig. 6.

Fig. 6.

Decreased mitochondrial priming by forced expression of BCL-XL is sufficient to switch the fate of p53-restored lymphoma cell lines to cell cycle arrest. (A) Forced expression of BCL-XL prevents caspase 3 cleavage after p53 restoration and (B) globally reduces mitochondrial priming in lymphoma cell lines. (C) Reduction of mitochondrial priming by BCL-XL expression as measured with BIM 0.75 μM. (D and E) Reduction of mitochondrial priming by BCL-XL expression significantly blunts p53 restoration-mediated apoptosis (D) and leads to a statistically significant decrease in the accumulation of S-phase p53-restored lymphoma cells and a concomitant accumulation in G1 and G2 (E). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.