Fig. 5.

Ectopic Wg expression rescues muscle degeneration caused by yki^3S/A tumors in the midgut. (A) Dorsal view of male flies. (B) Penetrance of downturned wing phenotype. n = 69 (esg-LexA::GAD^ts/Mhc.F3-580-GAL4; LexAOP-yki^3S/A/+), n = 71 (LexA::GAD^ts/Mhc.F3-580-GAL4; LexAOP-yki^3S/A/UAS-wg); male flies were used for five independent experiments. Mean ± SEMs are shown with individual data points. *P < 0.01, two-tailed unpaired Student’s t test. (C) Electron microscopic images of the transverse section of indirect flight muscles. # denotes mitochondria; ## denotes low electron-dense sector between myofibers. (D) Representative images of ovary. (E) Representative images of flies. The arrowhead indicates abdominal bloating. All transgenes were induced for 8 d. See also SI Appendix, Fig. S7.