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. 2021 May 31;8:669975. doi: 10.3389/fcvm.2021.669975

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Copyright © 2021 Rajgarhia, Ayasolla, Zaghloul, Lopez Da Re, Miller and Ahmed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell proliferation studies after transfection with SiRNA for RASSF1A—Cardiac fibroblasts were transfected with SiRNA for RASSF1A and compared to cells placed in RA which served as a control. BrdU cell proliferation studies were undertaken (A), and cells as having underwent cell counts (B). DNA methylation studies of the RASSF1A promotor region as shown in the heat map: RA group (samples 1–4); WT hypoxic group (Samples 6–9); TG hypoxic group (samples 11–15) (C). Quantitative estimation of methylation level among the three studied groups (D). Proposed mechanism (E). Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.