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. 2021 May 31;11:663416. doi: 10.3389/fcimb.2021.663416

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Copyright © 2021 Rusman, Floridia-Yapur, Tomasini and Diosque

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Variable gRNA diversity among strains. (A) Top, mHVR sequences with gRNA hits (dark grey) related to the number of analyzed mHVR sequences (light gray); bottom, number of gRNA classes (>20 reads) using a SWARM-like algorithm and detected for each strain (left column for each strain) and the average number of gRNA classes after down-sampling one-hundred times the number of paired-end reads to 950,000 (right column for each strain) with standard deviation bars. (B) Rarefaction curves for the number of gRNA classes (>20 reads) for each strain (solid lines, the color reference is according to (A). Dotted line is an extrapolation for MNcl2 based on a linear regression using last ten samples showing that increasing the sequencing depth will not significantly increase the number of detected gRNA classes.