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. 2021 May 31;12:666163. doi: 10.3389/fimmu.2021.666163

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Copyright © 2021 Bibert, Guex, Lourenco, Brahier, Papadimitriou-Olivgeris, Damonti, Manuel, Liechti, Götz, Tschopp, Quinodoz, Vollenweider, Pagani, Oddo, Hügli, Lamoth, Erard, Voide, Delorenzi, Rufer, Candotti, Rivolta, Boillat-Blanco, Bochud and the RegCOVID Study Group

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of differentially expressed genes (DEGs) sets for indicated pairwise comparisons. Groups used for comparisons (columns) include SARS-Cov-2 infected patients with no oxygen support [OXY0], oxygen support [OXY1], intubation with sampling within 7 days (TUBE early) or >7 days (TUBE late) after hospital admission, Influenza virus (INFL) infected patients and non-infected controls (HLTY). Significantly (adj. P-Value <=0.05) enriched genes sets (rows) are selected from different GO, REACTOME and/or KEGG pathways (see Supplementary Table 2 ), and their normalized enrichment score (NES) is indicated in each cell and used for coloring.