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Initiation phase: On the surface of a tissue factor (TF)-bearing cell, small amounts of thrombin (II) and factor IXa (IXa) are generated that then migrate to the surface of platelets. Amplification phase: Factors V, VIII, XI and platelets are activated. Propagation: On surface of activated platelet, activated factors assemble and generate thrombin burst. PS – phosphatidylserine. (Illustration made using Biorender)
