Figure 7.
Blocking necroptosis in STING-/- mice improves host defense during S.aureus infection. For one group of WT and STING-/- mice, 100 μL of 100 μM GW806742X was injected intraperitoneally 12 h and 1 h prior to infection with S.aureus (1 × 108 CFU/mouse). Mice were euthanized at 24 hpi to quantitate the bacterial burden in (A) BALF, (B) lung. (C) Total protein in BALF was measured. (D) The homogenate supernatant of the lung was also used to determine the activity of MPO. All data are shown as mean ± SEM. One-way ANOVA with Bonferroni’s multiple comparison test was performed. Statistical significance is indicated by *p < 0.05, **p < 0.01, and ***p < 0.001.