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. 2021 May 31;12:698275. doi: 10.3389/fphar.2021.698275

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Copyright © 2021 Feng, Feng, Zhang, Li and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Matrix stiffness induces pericytes to migrate away from pericyte spheroid and invade their surroundings. (A) Pericyte spheroids cultured on collagen-modified PA gels. (B) Statistical analysis of invasive cell numbers of pericytes cultured on different matrices. (C) Migration velocity of pericytes cultured on different matrices as measured by wound healing assay. (D) Representative images of pericyte spheroids encircled in A. Cell nuclei were stained with DAPI. Scale bar is 90 um.