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. 2021 May 28;12:678126. doi: 10.3389/fphar.2021.678126

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Copyright © 2021 Du, Zheng, Yu, Zhong, Li, Wu, Hu, Zhu, Xie, Xu, Zhan, Huang, Zeng, Zhang, Liu, Yin, Zha, Chan and Tsim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of prim-O-glucosylcimifugin as an active ingredient of YPFS in reversing cisplatin chemo-resistance. Prim-O-glucosylcimifugin (3 and 10 µM) were applied onto cultured A549 and A549-DDP cells. Assays of GST activity (A), gene expression of GSTPi1 (B) and GSTM1 (C), measurement of intracellular platinum (D), and cytotoxic activity (E, F) were performed and analyzed as described in Figures 1-3. Values are in mean ± SEM, n = 3. * or #, p < 0.05, ** or ##, p < 0.01, *** or ###, p < 0.001.