Fig. 7.1. Germinal zone migration in the developing cerebellum.
(a) Cerebellar granule neuron precursors (cGNPs) migrate tangentially (horizontal arrows) within the External Granule Layer (EGL). They then transition to a radial migration mode (vertical arrows) and migrate along glial fibers through the Molecular Layer (ML) and into the Internal Granule Layer (IGL). (b) Cereballarslice cultures electroporated with CGN-specific H2B-mCherry nuclei to track neuronal migration. At postnatal day 8 (P8, 24 h post electroporation), H2B-mCherry labeled CGNs migrate tangentially through the EGL. By P10 (72 h post electroporation) most CGNs have evacuated the EGL and migrated radially into the ML and IGL