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. Author manuscript; available in PMC: 2021 Jun 14.
Published in final edited form as: Adv Exp Med Biol. 2014;800:113–131. doi: 10.1007/978-94-007-7687-6_7

Fig. 7.3. PAR proteins and cytoplasmic Dynein directed minus-end transport.

Fig. 7.3

(a) Model of Dynein-directed minus-end transport of centrosome components mediated by PAR. This mechanism is responsible for proper centrosome motility. (b) Disruption of PAR protein components may result in inhibition of dynein mediated centrosome assembly and centrosome motility by PARD6 overexpression (Solecki et al. 2004), PARD6 RNAi (Kodani et al. 2010), and PARD3 depletion (Schmoranzer et al. 2009)