CENTRAL	Ovid MEDLINE	Ovid Embase
1 ("2019 nCoV" or 2019nCoV or "COVID 19" or COVID19 or "new coronavirus"       or "novel coronavirus" or "novel corona virus" or "SARS CoV‐2" or "2019‐        novel CoV" or ncov19 or ncov‐19) AND CENTRAL:TARGET 2 (Wuhan and (coronavirus or "corona virus")) AND CENTRAL:TARGET 3 ((coronavirus near3 2019) or ("corona virus" near3 2019)) AND      CENTRAL:TARGET   4 ((wuhan near2 disease) or (wuhan near2 virus)) AND CENTRAL:TARGET 5 ("LAMP assay" or "COVID‐19" or "COVID‐19 drug treatment" or "COVID‐19 diagnostic testing" or "COVID‐19 serotherapy" or "COVID‐19 vaccine" or "severe acute respiratory syndrome coronavirus 2" or "spike glycoprotein, COVID‐19 virus") AND CENTRAL:TARGET   6 #1 OR #2 OR #3 OR #4 OR #5          7 MESH DESCRIPTOR Mouthwashes EXPLODE ALL AND CENTRAL:TARGET 8 MESH DESCRIPTOR Nasal Sprays EXPLODE ALL AND   CENTRAL:TARGET   9 MESH DESCRIPTOR Nasal Lavage EXPLODE ALL AND CENTRAL:TARGET 10 (mouthwash* or gargl* or mouthrins*) AND CENTRAL:TARGET     11 (oral near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or           decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET   12 (mouth near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or       decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET   13 (nasal near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or        decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET   14 (nose near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or         decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET   15 (nasopharyngeal near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET 16 (larynx* near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or      decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET 17 (pharynx* near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or   decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET 18 (intranasal near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*)) AND CENTRAL:TARGET 19 MESH DESCRIPTOR Chlorhexidine EXPLODE ALL AND CENTRAL:TARGET 20 MESH DESCRIPTOR Povidone‐Iodine EXPLODE ALL AND          CENTRAL:TARGET 21 MESH DESCRIPTOR Cetylpyridinium EXPLODE ALL AND            CENTRAL:TARGET 22 MESH DESCRIPTOR Hexetidine EXPLODE ALL AND CENTRAL:TARGET 23 MESH DESCRIPTOR Anti‐Infective Agents, Local EXPLODE ALL AND    CENTRAL:TARGET 24 MESH DESCRIPTOR Hydrogen Peroxide EXPLODE ALL AND     CENTRAL:TARGET 25 MESH DESCRIPTOR Carbamide Peroxide EXPLODE ALL AND   CENTRAL:TARGET 26 MESH DESCRIPTOR Triclosan EXPLODE ALL AND CENTRAL:TARGET 27 MESH DESCRIPTOR Oils, Volatile EXPLODE ALL AND CENTRAL:TARGET 28 MESH DESCRIPTOR Plant Oils EXPLODE ALL AND CENTRAL:TARGET 29 MESH DESCRIPTOR Menthol AND CENTRAL:TARGET 30 MESH DESCRIPTOR Lavandula AND CENTRAL:TARGET 31 MESH DESCRIPTOR Thymus Plant AND CENTRAL:TARGET 32 MESH DESCRIPTOR Mentha piperita AND CENTRAL:TARGET 33 MESH DESCRIPTOR Cinnamomum zeylanicum AND CENTRAL:TARGET 34 MESH DESCRIPTOR Muramidase AND CENTRAL:TARGET 35 MESH DESCRIPTOR Lactoferrin AND CENTRAL:TARGET 36 MESH DESCRIPTOR Glucose Oxidase AND CENTRAL:TARGET 37 MESH DESCRIPTOR Lactoperoxidase AND CENTRAL:TARGET 38 (povidone or chlorhexidine or CHX or PVP or Polyvinylpyrrolidone or         Betadine* or Providine* or Disadine* or Isodine* or Pharmadine* or         Alphadine* or Betaisodona or Tubulicid or Novalsan or Sebidin or MK‐412A or      MK412A) AND CENTRAL:TARGET 39 (Chlorhexamed or Corsodyl or Curasept or Dyna‐Hex or Eludril or Gibitan or Hexidine or Hibiclens or Hibident or Hibiscrub or Hibisol or Hibitane or Peridex or avagard) AND CENTRAL:TARGET 40 (Hexadecylpyridinium or Cetylpyridium or Biosept or Ceepryn or Cetamium or       Catamium or Sterogenol or Dobendan or Merocets or Pristacin or Pyrisept or           Angifonil or Cetylyre) AND CENTRAL:TARGET 41 (Vagi‐Hex or Vagi Hex or VagiHex or Oraldene or Hexigel or Steri‐sol or Steri sol or Hextril or Oraldine or Oralspray or Hexoral or Bactidol or Elsix or      Duranil or Doreperol or Hexetidine) AND CENTRAL:TARGET        42 (Hydrogen Peroxide or H2O2 or Hydroperoxide or Superoxol or Oxydol or Perhydrol or Urea Peroxide or Perhydrol Urea) AND CENTRAL:TARGET   43 (Methyl salicylate or methylsalicylate or Rheumabal or Metsal Liniment or Hewedolor or Linsal) AND CENTRAL:TARGET 44 (Tricolsan or Hydroxydiphenyl or trichlorodiphenyl or Clearasil or Cliniclean or Irgasan or Trisan or Oxy Skin Wash or pHisoHex or Sapoderm or Tersaseptic or Aquasept or Ster‐Zac or Manusept or Microshield) AND CENTRAL:TARGET 45 ((spray* or douch* or irrigat* or rins* or wash* or lavag* or intranasal* or    topical) and (antimicrobial or anti‐microbial or disinfect* or antisept* or anti‐infect*)) AND CENTRAL:TARGET 46 ("essential oil*" or "plant oil*" or menthol or menthyl or (mint near2 oil*) or lavender or thyme or peppermint or "mentha piperita" or eugenol or       eucalyptus or "blue gum*" or cajeput or clove or cinnamon) AND    CENTRAL:TARGET 47 (muramidase or lysozyme* or leftose or lactoferrin or lactotransferrin or     "glucose oxidase" or lactoperoxidase or "saliva substitute") AND             CENTRAL:TARGET 48 (Listerine or Biotene) AND CENTRAL:TARGET 49 #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16         OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25   OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34          OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43      OR #44 OR #45 OR #46 OR #47 OR #48 50 #49 AND #6	1 ("2019 nCoV" or 2019nCoV or "COVID 19" or COVID19 or "new coronavirus"       or "novel coronavirus" or "novel corona virus" or "SARS CoV‐2" or "2019‐        novel CoV" or ncov19 or ncov‐19).ab,ti. 2 (Wuhan and (coronavirus or "corona virus")).ab,ti. 3 ((coronavirus or "corona virus") adj3 "2019").ab,ti. 4 (wuhan adj2 (disease or virus)).ab,ti. 5 ("LAMP assay" or "COVID‐19" or "COVID‐19 drug treatment" or "COVID‐19          diagnostic testing" or "COVID‐19 serotherapy" or "COVID‐19 vaccine" or           "severe acute respiratory syndrome coronavirus 2" or "spike glycoprotein, COVID‐19 virus").os. 6 1 or 2 or 3 or 4 or 5 7 exp Animals/ 8 exp Humans/ 9 7 not 8 10 (editorial or comment or letter or newspaper article).pt. 11 9 or 10 12 6 not 11 13 exp Mouthwashes/ 14 exp Nasal Sprays/ 15 exp Nasal Lavage/ 16 (mouthwash* or gargl* or mouthrins*).ab,ti. 17 ((oral or mouth or nasal or nose or nasopharyngeal or larynx* or pharynx* or intranasal) adj3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*)).ab,ti. 18 exp Chlorhexidine/ 19 exp Povidone‐Iodine/ 20 exp Cetylpyridinium/ 21 exp Hexetidine/ 22 exp Anti‐Infective Agents, Local/ 23 exp Hydrogen Peroxide/ 24 exp Carbamide Peroxide/ 25 exp Triclosan/ 26 exp Oils, volatile/ 27 exp Plant oils/ 28 Menthol/ 29 Lavandula/ 30 Thymus plant/ 31 Mentha piperita/ 32 Eugenol/ 33 Cinnamomum verum/ 34 Muramidase/ 35 Lactoferrin/ 36 Glucose oxidase/ 37 Lactoperoxidase/ 38 (povidone or chlorhexidine or CHX or PVP or Polyvinylpyrrolidone or Betadine* or Providine* or Disadine* or Isodine* or Pharmadine* or         Alphadine* or Betaisodona or Tubulicid or Novalsan or Sebidin or MK‐412A or MK412A).ab,ti. 39 (Chlorhexamed or Corsodyl or Curasept or Dyna‐Hex or Eludril or Gibitan or Hexidine or Hibiclens or Hibident or Hibiscrub or Hibisol or Hibitane or Peridex or avagard).ab,ti. 40 (Hexadecylpyridinium or Cetylpyridium or Biosept or Ceepryn or Cetamium or Catamium or Sterogenol or Dobendan or Merocets or Pristacin or Pyrisept or Angifonil or Cetylyre).ab,ti. 41 (Vagi‐Hex or Vagi Hex or VagiHex or Oraldene or Hexigel or Steri‐sol or Steri sol or Hextril or Oraldine or Oralspray or Hexoral or Bactidol or Elsix or Duranil or Doreperol or Hexetidine).ab,ti. 42 (Hydrogen Peroxide or H2O2 or Hydroperoxide or Superoxol or Oxydol or Perhydrol or Urea Peroxide or Perhydrol Urea).ab,ti. 43 (Methyl salicylate or methylsalicylate or Rheumabal or Metsal Liniment or Hewedolor or Linsal).ab,ti. 44 (Tricolsan or Hydroxydiphenyl or trichlorodiphenyl or Clearasil or Cliniclean or Irgasan or Trisan or Oxy Skin Wash or pHisoHex or Sapoderm or Tersaseptic or Aquasept or Ster‐Zac or Manusept or Microshield).ab,ti. 45 ((Spray* or douch* or irrigat* or rins* or wash* or lavag* or intranasal* or topical) adj3 (antimicrobial or anti‐microbial or disinfect* or antisept* or anti‐         infect*)).ab,ti. 46 ("essential oil$" or "plant oil$" or menthol or menthyl or (mint adj2 oil$) or   lavender or thyme or peppermint or "mentha piperita" or eugenol o eucalyptus or "blue gum$" or cajeput or clove or cinnamon).ab,ti. 47 (muramidase or lysozyme$ or leftose or lactoferrin or lactotransferrin or "glucose oxidase" or lactoperoxidase or "saliva substitute").ab,ti. 48 (Listerine or Biotene).ab,ti. 49 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26      or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or            40 or 41 or 42 or 43 or 44 or 45 or 46 or 47 or 48 50 12 and 49	1. ("2019 nCoV" or 2019nCoV or "COVID 19" or COVID19 or "new coronavirus" or "novel coronavirus" or "novel corona virus" or "SARS CoV‐2" or "2019‐        novel CoV" or ncov19 or ncov‐19).ab,ti.        2. (Wuhan and (coronavirus or "corona virus")).ab,ti.    3. ((coronavirus or "corona virus") adj3 "2019").ab,ti.    4. (wuhan adj2 (disease or virus)).ab,ti. 5. ("LAMP assay" or "COVID‐19" or "COVID‐19 drug treatment" or "COVID‐19 diagnostic testing" or "COVID‐19 serotherapy" or "COVID‐19 vaccine" or "severe acute respiratory syndrome coronavirus 2" or "spike glycoprotein, COVID‐19 virus").ti,ab.           6. or/1‐5  7. mouthwash/    8. nose spray/     9. nasal lavage/  10. (mouthwash* or gargl* or mouthrins*).ab,ti.   11. ((oral or mouth or nasal or nose or nasopharyngeal or larynx* or pharynx* or intranasal) adj3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*)).ab,ti.    12. chlorhexidine/ 13. povidone iodine/         14. cetylpyridinium salt/    15. hexetidine/      16. exp topical antiinfective agent/           17. hydrogen peroxide/     18. carbamide peroxide/   19. triclosan/         20. essential oil/    21. menthol/          22. lavender/         23. thymus extract/           24. Mentha piperita/          25. eugenol/          26. Cinnamomum zeylanicum/     27. lysozyme/        28. lactoferrin/       29. Glucose oxidase/        30. Lactoperoxidase/        31. (povidone or chlorhexidine or CHX or PVP or Polyvinylpyrrolidone or Betadine* or Providine* or Disadine* or Isodine* or Pharmadine* or         Alphadine* or Betaisodona or Tubulicid or Novalsan or Sebidin or MK‐412A or MK412A).ab,ti.            32. (Chlorhexamed or Corsodyl or Curasept or Dyna‐Hex or Eludril or Gibitan or Hexidine or Hibiclens or Hibident or Hibiscrub or Hibisol or Hibitane or Peridex or avagard).ab,ti.       33. (Hexadecylpyridinium or Cetylpyridium or Biosept or Ceepryn or Cetamium or Catamium or Sterogenol or Dobendan or Merocets or Pristacin or Pyrisept or           Angifonil or Cetylyre).ab,ti.     34. (Vagi‐Hex or Vagi Hex or VagiHex or Oraldene or Hexigel or Steri‐sol or Steri sol or Hextril or Oraldine or Oralspray or Hexoral or Bactidol or Elsix or Duranil or Doreperol or Hexetidine).ab,ti.      35. (Hydrogen Peroxide or H2O2 or Hydroperoxide or Superoxol or Oxydol or             Perhydrol or Urea Peroxide or Perhydrol Urea).ab,ti.            36. (Methyl salicylate or methylsalicylate or Rheumabal or Metsal Liniment or Hewedolor or Linsal).ab,ti.     37. ((spray* or douch* or irrigat* or rins* or wash* or lavag* or intranasal* or topical) adj3 (antimicrobial or anti‐microbial or disinfect* or antisept* or anti‐         infect*)).ab,ti.  38. (Tricolsan or Hydroxydiphenyl or trichlorodiphenyl or Clearasil or Cliniclean or Irgasan or Trisan or Oxy Skin Wash or pHisoHex or Sapoderm or Tersaseptic       or Aquasept or Ster‐Zac or Manusept or Microshield).ab,ti.  39. ("essential oil$" or "plant oil$" or menthol or menthyl or (mint adj2 oil$) or   lavender or thyme or peppermint or "mentha piperita" or eugenol or eucalyptus or "blue gum$" or cajeput or clove or cinnamon).ab,ti.   40. (muramidase or lysozyme$ or leftose or lactoferrin or lactotransferrin o "glucose oxidase" or lactoperoxidase or "saliva substitute").ab,ti.            41. (Listerine or Biotene).ab,ti.     42. or/7‐41 43. 6 and 42
WHO COVID‐19 Register	Cochrane COVID‐19 Register	—
(tw:((oral or mouth or nasal or nose or nasopharyngeal or larynx* or pharynx* or intranasal) )) AND (tw:(spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*)) (tw:((mouthwash* or gargl* or mouthrins*))) (tw:((spray* or douch* or irrigat* or rins* or wash* or lavag* or intranasal* or topical))) AND (tw:((antimicrobial or anti‐microbial or disinfect* or antisept* or anti‐infect*))) (povidone or chlorhexidine or CHX or PVP or Polyvinylpyrrolidone or Betadine* or Providine* or Disadine* or Isodine* or Pharmadine* or Alphadine* or Betaisodona or Tubulicid or Novalsan or Sebidin or MK‐412A or MK412A)	1 (mouthwash* or gargl* or mouthrins*)  AND INREGISTER 2 (oral near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 3 (mouth near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 4 (nasal near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 5 (nose near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 6  (nasopharyngeal near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 7 (larynx* near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 8 (pharynx* near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or   decontaminat* or aerosol or mist or clean*))  AND INREGISTER            9 (intranasal near3 (spray* or douch* or irrigat* or lavag* or wash or rins* or decontaminat* or aerosol or mist or clean*))  AND INREGISTER 10 (povidone or chlorhexidine or CHX or PVP or Polyvinylpyrrolidone or Betadine* or Providine* or Disadine* or Isodine* or Pharmadine* or Alphadine* or Betaisodona or Tubulicid or Novalsan or Sebidin or MK‐412A or MK412A)  AND INREGISTER 11 (Chlorhexamed or Corsodyl or Curasept or Dyna‐Hex or Eludril or Gibitan or Hexidine or Hibiclens or Hibident or Hibiscrub or Hibisol or Hibitane or  Peridex or avagard) AND INREGISTER 12 (Hexadecylpyridinium or Cetylpyridium or Biosept or Ceepryn or Cetamium or Catamium or Sterogenol or Dobendan or Merocets or Pristacin or Pyrisept or Angifonil or Cetylyre) AND INREGISTER 13 (Vagi‐Hex or Vagi Hex or VagiHex or Oraldene or Hexigel or Steri‐sol or Steri sol or Hextril or Oraldine or Oralspray or Hexoral or Bactidol or Elsix or Duranil or Doreperol or Hexetidine)  AND INREGISTER 14 (Hydrogen Peroxide or H2O2 or Hydroperoxide or Superoxol or Oxydol or Perhydrol or Urea Peroxide or Perhydrol Urea)  AND INREGISTER 15 (Methyl salicylate or methylsalicylate or Rheumabal or Metsal Liniment or  Hewedolor or Linsal)  AND INREGISTER 16 (Tricolsan or Hydroxydiphenyl or trichlorodiphenyl or Clearasil or Cliniclean or Irgasan or Trisan or Oxy Skin Wash or pHisoHex or Sapoderm or Tersaseptic       or Aquasept or Ster‐Zac or Manusept or Microshield)  AND INREGISTER 17 ((Spray* or douch* or irrigat* or rins* or wash* or lavag* or intranasal* or    topical) and (antimicrobial or anti‐microbial or disinfect* or antisept* or anti           infect*))  AND INREGISTER 18 ("essential oil*" or "plant oil*" or menthol or menthyl or (mint near2 oil*) or  lavender or thyme or peppermint or "mentha piperita" or eugenol or eucalyptus or "blue gum*" or cajeput or clove or cinnamon)  AND   INREGISTER 19 (muramidase or lysozyme* or leftose or lactoferrin or lactotransferrin or "glucose oxidase" or lactoperoxidase or "saliva substitute")  AND    INREGISTER 20 (Listerine or Biotene) AND INREGISTER 21 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20	—