Fig. 1.

Graphical summary of gene editing system delivery into the mitochondria. Protein or RNA component can be imported through lentivirus transfection and nuclear genome expression while modified by MTS or RP-Loop. DNA component can be imported through liposome transfection or other methods. The blue-color mitochondria stand for mitochondria containing mutated mtDNA (target site of gene editing system) while the yellow-color mitochondria stand for wild-type mitochondria. (RE:Restriction endonuclease; ZFN:Zinc Finger Nuclease; TALEN:Transcription Activator-Like Effectors Nuclease; CRISPR:Clustered regularly interspaced short palindromic repeats; pAgo:prokaryotic Argonaute proteins). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)