Skip to main content
[Preprint]. 2021 Jun 16:2021.06.07.447287. Originally published 2021 Jun 7. [Version 2] doi: 10.1101/2021.06.07.447287

Fig. 4. COVID-19 driven reprogramming of platelets leads to drastically altered expression of genes associated with platelet adhesion, activation, coagulation and thrombosis.

Fig. 4.

(A-B) Uniform Manifold Approximation and Projections (UMAPs) show distributions of sub-clusters (A) and COVID-19 conditions (B) of platelets after the integration of PBMC datasets. (C) Severity-associated coagulation genes were selected and shown on the heatmap, with disease and sub-cluster specific gene patterns identified and labeled. Their functional associations with coagulation pathways were retrieved from ToppGene and shown on the right. (D) Functional and phenotypical associations of coagulation-association genes in each gene pattern from (B). Associations were retrieved from ToppGene enrichment. Fibrinolysis is highlighted.