TABLE 2.
VE for 3 vs 0 RV Doses Among Children Aged 8 Months or Older
| Age ≥ 8 mo | Source of Immunization Data | Minnesota |
Georgia |
Minnesota + Georgia + Connecticut |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases |
Controls |
VE (95% CI) | Cases |
Controls |
VE (95% CI) | Cases |
Controls |
VE (95% CI) | ||||||||
| n | n (%) Vaccinated | n | n (%) Vaccinated | n | n (%) Vaccinated | n | n (%) Vaccinated | n | n (%) Vaccinated | n | n (%) Vaccinated | |||||
| Controls: rotavirus-negative | IIS | 170 | 18 (11) | 180 | 87 (48) | 90 (80–95) | 95 | 4 (4) | 135 | 43 (32) | 91 (70–97) | 283 | 23 (8) | 341 | 141 (41) | 89 (81–94)a |
| IIS, restricted | 106 | 18 (17) | 138 | 87 (63) | 93 (83–97) | 66 | 4 (6) | 107 | 43 (40) | 90 (66–97) | 188 | 23 (12) | 265 | 141 (53) | 90 (82–95)a | |
| IIS + provider | 120 | 23 (19) | 175 | 115 (66) | 92 (84–96) | 61 | 5 (8) | 105 | 48 (46) | 91 (72–97) | 181 | 28 (15) | 279 | 163 (58) | 90 (84–94)b | |
| IIS + provider, restricted | 96 | 22 (23) | 164 | 115 (70) | 93 (85–97) | 47 | 5 (11) | 93 | 48 (52) | 91 (70–97) | 143 | 27 (19) | 257 | 163 (63) | 91 (83–95)b | |
| Controls: IIS (matched) | IIS | 170 | 18 (11) | 1510 | 590 (39) | 88 (79–93) | 95 | 4 (4) | 836 | 225 (27) | 95 (82–98) | 283 | 23 (8) | 2520 | 850 (34) | 89 (83–93)c |
| IIS, restricted | 106 | 18 (17) | 1114 | 588 (53) | 94 (86–97) | 66 | 4 (6) | 581 | 225 (39) | 96 (82–99) | 188 | 23 (12) | 1847 | 848 (46) | 94 (88–97)c | |
Restricted indicates that analysis was restricted to those children whose IIS record (or provider record, for those with provider records) indicated that the child had received 3 doses of RV, DTaP, IPV, or PCV through 8 months of age, stated that the child was delayed on immunizations, or that the parents had refused immunizations. Eight children were in the last 2 categories combined. Results with only an IIS as the source of immunization data are from seasons 1 through 3 combined. Results with combined IIS and provider as the sources of immunization data are from seasons 2 and 3 combined.
VE estimates were the same when the model controlled for specific hospital in Georgia or Minnesota and insurance status (private versus public/none), in addition to site, season, and birth quarter. Therefore, the final model included only site, season, and birth quarter. IIS data from 2 rotavirus-negative controls from Minnesota indicated receipt of 4 RV doses.
Overall results using IIS plus provider records are from Georgia and Minnesota combined. IIS data from 2 rotavirus-negative controls from Minnesota indicated receipt of 4 RV doses.
Data from 14 IIS controls from Minnesota and 1 from Georgia indicated receipt of 4 RV doses.