TABLE 3.
VE for 3 vs 0 RV Doses, According to Subsets of Age and Hospital Setting Among Children Aged ≥8 Months
| Source of Immunization Data | Minnesota + Georgia + Connecticut |
|||||
|---|---|---|---|---|---|---|
| Cases |
Controls |
VE (95% CI) | ||||
| n | n (%) Vaccinated | n | n (%) Vaccinated | |||
| VE for 3 vs 0 doses, according to age | ||||||
| Controls: rotavirus-negative | ||||||
| 8–11 mo | IIS + provider | 24 | 4 (17) | 92 | 63 (68) | 93 (75–99)a,b |
| 12–23 mo | IIS + provider | 102 | 21 (21) | 147 | 86 (59) | 89 (77–94)a |
| ≥24 mo | IIS + provider | 55 | 3 (5) | 41 | 14 (34) | 91 (62–99)a,b |
| IIS + provider, restricted | 45 | 3 (7) | 35 | 14 (40) | 92 (63–99)a,c | |
| Controls: IIS (matched) | ||||||
| 8–11 mo | IIS | 109 | 3 (3) | 1009 | 194 (19) | 94 (78–99) |
| 12–23 mo | IIS | 116 | 17 (15) | 988 | 517 (52) | 88 (80–93) |
| ≥24 mo | IIS | 58 | 3 (5) | 523 | 139 (27) | 87 (56–96) |
| IIS, restricted | 40 | 3 (8) | 372 | 138 (37) | 86 (50–96) | |
| VE for 3 vs 0 doses among children aged ≥8 mo, according to case hospital setting | ||||||
| Controls: rotavirus-negative | ||||||
| Inpatient/short-stay cases | IIS + provider | 140 | 20 (14) | 280 | 163 (58) | 92 (86–96)a |
| ED cases | IIS + provider | 41 | 8 (20) | 280 | 163 (58) | 81 (53–92)a |
| Controls: IIS (matched) | ||||||
| Inpatient/short-stay cases | IIS | 221 | 17 (8) | 1953 | 672 (34) | 90 (84–94) |
| ED cases | IIS | 62 | 6 (10) | 567 | 138 (31) | 84 (58–94) |
Restricted indicates that analysis was restricted to those children whose IIS record (or provider record, for those with provider records) indicated that the child had received 3 doses of RV, DTaP, IPV, or PCV through 8 months of age, stated that the child was delayed on immunizations, or that the parents had refused immunizations. Eight children were in the last 2 categories combined. Results with only an IIS as the source of immunization data are from seasons 1 through 3 combined. Results with combined IIS and provider as the sources of immunization data are from seasons 2 and 3 combined.
Results using IIS plus provider records are from Georgia and Minnesota combined. The model included site, season, and birth quarter.
Exact logistic regression.
Exact logistic regression; median age of vaccinated rotavirus-negative controls: 27.8 months (interquartile range: 27.1–29.6).