TABLE 4.
VE for 2 and 1 RV Dose Versus 0 Doses
| Source of Immunization Data | Minnesota + Georgia + Connecticut |
|||||
|---|---|---|---|---|---|---|
| Cases |
Controls |
VE (95% CI) | ||||
| n | n (%) Vaccinated | n | n (%) Vaccinated | |||
| VE for 2 vs 0 doses, age ≥ 8 mo | ||||||
| Controls: rotavirus-negative | IIS + provider | 160 | 7 (4) | 153 | 36 (24) | 90 (75 to 96)a |
| IIS + provider, restricted | 117 | 1 (1) | 114 | 20 (18) | 98 (79 to 100)a,b | |
| Controls: IIS (matched) | IIS | 268 | 8 (3) | 1962 | 292 (15) | 91 (79 to 96) |
| IIS, restricted | 165 | 0 (0) | 1116 | 117 (10) | 100 (NA) | |
| VE for 1 vs 0 doses, age 6 wk through 5 mo | ||||||
| Controls: rotavirus-negative | IIS | 69 | 11 (16) | 248 | 97 (39) | 71 (40 to 87)c |
| IIS, restricted | 44 | 9 (20) | 176 | 82 (47) | 66 (16 to 86)d | |
| Controls: IIS (matched) | IIS | 69 | 11 (16) | 633 | 184 (29) | 62 (20 to 82) |
| IIS, restricted | 44 | 9 (20) | 376 | 144 (38) | 66 (11 to 87) | |
| VE for 1 vs 0 doses, age ≥ 8 moe | ||||||
| Controls: rotavirus-negative | IIS + provider | 163 | 10 (6) | 137 | 20 (15) | 69 (27 to 87)a |
| IIS + provider, restricted | 125 | 9 (7) | 106 | 12 (11) | 47 (−41 to 80)a | |
Restricted indicates that analysis was restricted to those children whose IIS record (or provider record, for those with provider records) indicated that the child had received 3 doses of RV, DTaP, IPV, or PCV through 8 months of age, stated that the child was delayed on immunizations, or that the parents had refused immunizations. Eight children were in the last 2 categories combined. Results with only an IIS as the source of immunization data are from seasons 1 through 3 combined. Results with combined IIS and provider as the sources of immunization data are from seasons 2 and 3 combined.
Results using IIS plus provider records are from Georgia and Minnesota combined. The model included site, season, and birth quarter.
Median age vaccinated rotavirus-negative controls: 13.8 months (interquartile range: 10.6–18.1).
Median age: rotavirus cases, 3.8 months; rotavirus-negative controls, 3.6 months. The model included site, season, and birth quarter.
Median age: rotavirus cases, 3.8 months; rotavirus-negative controls, 3.5 months. The model included site, season, and birth quarter.
VE for 1 vs 0 RV doses using IIS controls is not presented for age of 8 months or older because of concerns with missing additional RV doses in this group in the absence of provider records.