Table 2.

Accounts of possible personality changes after LSD or psilocybin treatment in 38/151 patients^∗.

Primary ICD-6 or ICD-8 psychiatric diagnosis	Account of personality change	Long-term unwanted effect (1986−1988)	LSD dose-effect index†/N‡/max dose (μg)
1 Depressive neurosis	Mortal dread, split mind, changed	Flashbacks, depression§	11,2/14/80
2 Depression	She becomes sexually aroused when she watches men's trousers	Flashbacks, psychosis¶	–/6/–
3 Anorexia nervosa	Mood swings	Flashbacks	24/3/800
4 Personality disorder	Alternately crying and being euphorically silly	Flashbacks, depression§	148,5/27/550
5 Anankastic neurosis	Crying and screaming with self-hatred	Flashbacks	– /9/–
6 Anxiety neurosis	Impaired defense mechanisms	Flashbacks	–/12/–
7 Depression	Denies any emotional change, but deeply attached to the doctor	Flashbacks, psychosis¶	–/–/–
8 Anxiety neurosis	Realizes own aggressive inclinations	Flashbacks	26/65/250
9 Depression	Impulsivity, uncontrolled behavior	Flashbacks	2,5/5/50
10 Anxiety neurosis	Unable to separate reality from fantasy	Flashbacks	–/20/–
11 Paranoid psychosis	Released uncontrollable strengths	Psychosis¶	7,5/3/250
12 Character neurosis	LSD made him more “soft-minded”	Flashbacks	–/7/–
13 Anxiety neurosis	More likely to act on impulse	Depression§	–/3/–
14 Depressive neurosis	Like brainwashing, more outspoken	Flashbacks	–/30/–
15 Stuttering	Afraid of impulsive-ness, did not dare to handle firearms	Flashbacks	13/13/100
16 Anxiety neurosis	Temporary success, though horrifying	Flashbacks	–/18/–
17 Anxiety neurosis	More outspoken, boundless thoughts, scary changes	Flashbacks	–/5/–
18 Character neurosis	Outbursts of weeping	Flashbacks	24/30/80
19 Character neurosis	Deteriorated memory, “dried-up”	Flashbacks	–/6/–
20 Character neurosis	Never escaped from LSD intoxication		96/32/300
21 Depressive neurosis	Momentarily unstable, smashed a TV	Flashbacks	37,5/15/250
22 Depression	Colleagues did not recognize him	Flashbacks	–/3/–
23 Character neurosis	Terrified due to experience of own death	Flashbacks	136,5/21/650
24 Character neurosis	Became overexcited (“hypomania”?)	Depression§	1,5/1/150
25 Character neurosis	Though deteriorated, regretful of early termination of LSD-treatment	Flashbacks	–/36/–
26 Anxiety neurosis	Looser in way of thinking	Flashbacks	14/14/10
27 Sexual neurosis	Developed constant nervousness after LSD applied to treat homosexuality	Flashbacks, depression§	60/30/200
28 Personality disorder	Feels like a much older man than corresponds to chronological age	Flashbacks	376/47/800
29 Schizophrenia	Sexually aroused during LSD-treatment	Flashbacks, psychosis¶	51/17/300
30 Unspecified neurosis	No longer able to solve mathematical problems	Flashbacks	–/32/–
31 Depressive neurosis	After LSD-treatment, considered to be an almost insane person	Flashbacks, depression§	70/14/500
32 Depression	“Went to pieces” after psilocybin treatment	Psychosis¶	17 weekly sessions, 6–24 mg
33 Anxiety neurosis	More frank, almost silly after psilocybin treatment	Psychosis¶	16 weekly sessions, 4–32 mg
34 Anxiety neurosis	More talkative, gets talking with complete strangers	Flashbacks	30/15/200
35 Depression	Positive response to LSD-treatment, which was considered to be as well pleasant as unpleasant	Flashbacks	51,3/19/270
36 Unspecified neurosis	Wife considered her husband not to be the same person as before LSD-treatment		62,1/23/270
37 Anxiety neurosis	Felt in excellent spirits one week after end of LSD-treatment		12/12/100
38 Anxiety neurosis	More unbalanced after LSD-treatment	Psychosurgical intervention	8,75/7/125

^∗Diagnosis per the 6^th (ICD-6) or 8^th (ICD-8) editions of the international Classifications of Diseases at the time of the psychedelic treatment, 1960–1974.

^†LSD dose effect index: Maximal LSD dose multiplied by the number of sessions, divided by 100.

^‡N: Number of sessions.

^§Further development of bipolar disorder or depressive disorder.

^¶Further development of schizophrenia or delusional disorder.