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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Pharmacol Ther. 2021 May 14;223:107892. doi: 10.1016/j.pharmthera.2021.107892

Fig. 3.

Fig. 3

Identification of B7-H3 isoforms. (A) B7-H3 is a type I transmembrane protein that belongs to the Ig superfamily. 2IgB7-H3 exists in both human and mouse, whereas 4IgB7-H3 only exists in human. 4Ig-B7-H3 isofom consists of two pairs of VC-like Ig domains, forming a structure of single peptide-IgV-IgC-IgV-IgC-TM-cytoplasmic tail. In addition, soluble isoform B7-H3 (sB7-H3) exists in both mouse and human serum/plasma. (B) Sequence alignment of human 4IgB7-H3 with 2IgB7-H3 isoform of both human and mouse. The leader peptide is indicated by black solid line; IgV- and IgC-like domains are indicated by red and green lines; transmembrane region is indicated by purple line; cytoplasmic tail is indicated by blue line.