Figure 3.

The alterations of mechanical threshold, dynamic allodynia and pinprick hyperalgesia scores following administration of GsMTx4. After the contraction injury of the trigeminal nerve, the mechanical threshold began to decrease significantly at day 7, reaching bottom at day 14 and remaining at a low level until the last time point of day 21. Coincidentally, the dynamic allodynia and pinprick hyperalgesia scores changed correspondingly (A–C). An hour after intraperitoneal administration of GsMTx4 in those TN model rats, the mechanical threshold, dynamic allodynia and pinprick hyperalgesia scores start to change significantly compared to those with saline administration (D–F).