Table 1. Cytokine and chemokine levels measured in brainstem protein lysates using a multiplex assay in young (4 months) and aged (24 months) C57BL/6J mice.

Cytokines (pg/μg protein)	Young (mean±SE)	Aged (mean±SE)	p-value
Eotaxin	0.292±0.01	0.557±0.04	0.0003
G-CSF	0.515±0.04	0.781±0.06	0.007
GM-CSF	1.40±0.09	1.324±0.07	0.536
IFN-gamma	0.282±0.03	0.275±0.02	0.86
IL-1a	2.811±0.21	3.09±0.20	0.378
IL-1b	0.974±0.10	1.059±0.08	0.532
IL-2	0.704±0.06	0.661±0.05	0.583
IL-3	0.109±0.01	0.144±0.006	0.02
IL-5	0.096±0.01	0.097±0.01	0.953
IL-6	0.157±0.02	0.188±0.01	0.147
IL-7	0.242±0.02	0.230±0.02	0.705
IL-9	7.292±1.0	6.734±0.35	0.561
IL-10	3.238±0.30	3.312±0.25	0.854
IL-12 (P40)	0.578±0.05	0.615±0.06	0.66
IL-12 (P70)	1.576±0.15	1.525±0.11	0.787
IL-13	2.686±0.29	3.186±0.35	0.319
IL-15	3.53±0.25	3.331±0.21	0.552
IL-17	0.073±0.006	0.076±0.004	0.75
IP-10	0.827±0.04	3.293±0.42	0.0006
KC	0.819±0.06	1.231±0.09	0.007
LIF	0.054±0.003	0.091±0.006	0.001
LIX	1.957±0.20	2.199±0.22	0.464
MCP1	1.036±0.09	1.515±0.06	0.0009
M-CSF	2.127±0.22	2.915±0.16	0.01
MIG	0.389±0.04	0.588±0.14	0.273
MIP-1a	1.332±.012	1.595±0.1	0.121
MIP-1b	1.492±0.12	1.864±0.11	0.04
MIP-2	2.891±0.18	3.059±0.15	0.497
RANTES	0.780±0.06	1.669±0.07	<0.005
TNFa	0.207±0.02	0.226±0.02	0.46
VEGF	0.104±0.01	0.092±0.01	0.524

Significant changes are highlighted in bold text (p < 0.05).