Table 7. Effects of Sirt1 overexpression on heart functions in HF rats.
Group | LVPWD (mm) | IVSD (mm) | LVEDD (mm) | LVESD (mm) | LVEF (%) | FS (%) |
Model + oe-NC | 0.97±0.12 | 1.36±0.14 | 3.65±0.84 | 1.87±0.24 | 34.18±3.76 | 17.08±1.19 |
Model + oe-Sirt1 | 1.42±0.16* | 0.68±0.12* | 1.62±0.23* | 0.97±0.15* | 70.31±7.79* | 24.07±3.06* |
Note: *p < 0.05 vs. model + oe-NC group. HF, heart failure; NC, negative control; LVPWD, left ventricular posterior wall thickness; IVSD, interventricular septal dimension; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; FS, fractional shortening.