Table 2.

Inhibitory effects of nitroxide-NSAID conjugates on COX-induced PGE₂ in NSCLC A549 cells.

Compound	Concentration (μM)	PGE2, pg.mL
None		57 ± 4
4	30	50 ± 5
5	30	52 ± 5
27	30	31 ± 4*
28	30	54 ± 6
29	30	45 ± 9
34	30	34 ± 6*
39	30	58 ± 3
41	30	23 ± 5*
42	30	21 ± 6*

The mean value ± S.D. or 3 determinations each repeated in duplicate is indicated using A549 cells

^*p < 0.05

^**p < 0.01, using the Student’s t-test