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. Author manuscript; available in PMC: 2021 Jun 14.
Published in final edited form as: Eur J Med Chem. 2018 Jan 31;147:34–47. doi: 10.1016/j.ejmech.2018.01.077

Table 3.

Comparison of individual components with nitroxide-NSAID conjugates on inhibiting of COX-induced PGE2 in NSCLC A549 cells.

Compound Concentration (μM) PGE2, pg.mL
None 126 ± 17
Aspirin 90 79 ± 11
Tempol 90 105 ±11
Aspirin + Tempol 90 75 ± 14*
27 4 87 ± 9*
28 4 99 + 13

The mean value ± S.D. or 3 determinations each repeated in duplicate is indicated using A549 cells

*

p < 0.05

**

p < 0.01, using the Student’s t-test