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. 2021 Jun 9;15:2445–2456. doi: 10.2147/DDDT.S308377

Table 2.

Peptide Inhibitors Block the YAP-TEAD Interactions

Ref Name/Patent Number Mechanism
[35] Super-TDU Directly targeted TEADs and reduced the YAP-TEAD interaction
[48] Peptide 17 Potent cyclic peptide inhibitors of the YAP-TEAD interaction
[49] Rubiaceae type cyclic peptide Inhibited YAP-TEAD transcription activity
[50] US20160264636A1 A derived chimeric peptide linked to a cell-penetrating peptide inhibiting the interaction between the TEAD and YAP or TAZ proteins
[51] CN104558119A Inhibited the bonding activity of the YAP protein and TEAD
[52] CN105524139A Inhibited the bonding activity of the YAP protein and TEAD
[53] WO2015022283A1 Inhibited the bonding activity of the YAP protein and TEAD