Mojsa 2017.

Study characteristics
Methods	Study design: parallel‐group randomized controlled trial Sample size: 60 Country: Poland Setting: secondary care hospital Dates conducted: not reported Postoperative opioid used and delivery: none Pain score collection: surgeon Concurrent postoperative analgesics: none reported
Participants	Inclusion criteria Surgical extraction of a partially or totally impacted lower third molar (Pell and Gregory classification IIB or IIIB), with no associated inflammation of the tissue Aged 18–50 years old General good health Exclusion criteria Allergy to paracetamol, lornoxicam, aspirin or any other NSAID Lactose intolerance Pregnancy or breastfeeding Any analgesic intake in the 24 hours immediately prior to the surgery
Interventions	Group A (30 participants): PO lornoxicam 60 mg 60 minutes before surgery and placebo 60 minutes after surgery Group B (30 participants): placebo 60 minutes before surgery and PO lornoxicam 60 mg 60 minutes after surgery
Outcomes	Postoperative pain (sum of the grading of the level of pain at 1, 2, 4, 6, 8, 12 and 24 hours after surgery) Paracetamol consumption (mg consumed at 24 hours) Adverse events (not specified which at 24 hours) Time to analgesic request (hours)
Notes	Funding: "no funding to declare" Declarations of interest: "none declared" Authors contacted: yes (data received from authors for VAS pain scores) Other: time to analgesia time‐to‐event but not enough information to extract data. Early pain score from 2 hours to allow post‐incision dose to take effect
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers. Quote: "random number generator"
Allocation concealment (selection bias)	Low risk	Opaque envelopes. Quote: "To ensure allocation concealment, 90 identical non‐transparent sequentially numbered envelopes were used".
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐dummy placebo used. Quote: "Identical unmarked capsules containing either 16 mg of lornoxicam or the same weight of placebo were administered".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Likely blinded from above
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants analysed. Quote: "No data were missing, and all patients included in the present study attended all study visits".
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Low risk	Similar baseline characteristics and no industry funding. Quote: "There was no difference between the three study groups in terms of age (P = 0.325) or sex distribution (P = 0.526), surgical difficulty of the procedure (P = 0.721) or duration of surgery (P = 0.919)".