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. 2021 Jun 14;2021(6):CD012978. doi: 10.1002/14651858.CD012978.pub2

Aoki 2002.

Methods Study design: parallel‐group randomized controlled trial
Sample size: 40
Country: Japan
Setting: secondary care hospital
Dates conducted: not reported
Postoperative opioid used and delivery: not reported
Pain score collection: not reported
Concurrent postoperative analgesics: not reported
Participants Inclusion criteria
  1. Minor ear, neck and nose surgery


Exclusion criteria (not reported)
Interventions Group Second (20 participants): 1 mg/kg flurbiprofen IV at the end of surgery
Group Third (20 participants): 1 mg/kg IV flurbiprofen before the start of surgery
Outcomes
  1. Number requiring analgesia (%)

  2. Time without analgesics

  3. Serum concentration of flurbiprofen

  4. Postoperative pain

Notes Funding: not reported
Declarations of interest: not reported
Authors contacted: yes
Other: not included as unable to translate. Concluded "...administration of flurbiprofen before the start of surgery is more effective for peri‐operative analgesia in minor ear, neck and nose surgery".