Table 3.
Effects of NSAIDs on the MICs of the antibiotics (fold-change decrease in the MICs of antibiotics, *: fold-change increase).
| Drugs | Bacteria | |||
|---|---|---|---|---|
| MRSA#1 | MRSA#2 | MRSA#3 | ATCC | |
| MOX+ASA | - | - | - | 1.25 |
| MOX+ACE | - | - | - | 1.25 |
| MOX+DIC | 1.33 | 1.66 | - | 1.25 |
| MOX+IBU | - | - | - | 1.25 |
| MOX+NAP | - | - | 1.66 | 1.25 |
| CIP+ASA | - | - | - | - |
| CIP+ACE | - | 1.66 | - | 1.66 |
| CIP+DIC | 4 | 3.33 | 2 | 4 |
| CIP+IBU | - | - | - | *1.2 |
| CIP+NAP | - | - | - | *1.2 |
| VAN+ASA | - | 1.33 | 1.33 | - |
| VAN+ACE | - | - | - | - |
| VAN+DIC | 2.33 | - | - | 1.66 |
| VAN+IBU | 1.33 | - | 1.33 | - |
| VAN+NAP | 2 | - | 2 | 2 |
| CLI+ASA | - | - | - | - |
| CLI+ACE | 1.66 | 1.66 | 1.66 | - |
| CLI+DIC | 6.66 | 6.66 | 6.66 | 2.33 |
| CLI+IBU | - | 3.33 | - | - |
| CLI+NAP | - | 2.66 | - | - |
| GEN+ASA | 1.33 | 1.66 | 2 | 1.25 |
| GEN+ACE | 4 | 4 | 1.6 | 1.25 |
| GEN+DIC | 6.66 | 6.66 | 5.6 | 2.5 |
| GEN+IBU | 6.66 | 5.33 | 4 | 3 |
| GEN+NAP | 6.66 | 8 | 4.8 | 2.5 |
MOX: moxifloxacin, CIP: ciprofloxacin, VAN: vancomycin, CLI: clindamycin, GEN: gentamicin, (-): no alteration, the data was the mean of three replicates.