Table 3.

Circulating miRNA-21 expression comparison between premenopause and menopause subjects.

Variable	Groups	Premenopause	Menopause	miRNA-21expression change	P
miRNA-21 expression(2-ΔΔCt)	Healthy control subjects (n = 16)	1.123(0.758-4.532)a	0.651(0.164-0.414)a	0.578 times decrease	0.031c
	Breast cancersubjects (n = 26)	3.500 ± 1.517b	6.021 ± 3.583b	1.720 times increase	0.022d
	Total (n = 42)	2.594(0.758-6.916)a	2.912(0.164-11.794)a	1.123 times increase	0.929c