Table 1.

The SPECT and PET radiotracers used for the evaluation of striatal dopaminergic neurotransmission in PD and parkinsonian disorders [4–8, 10].

Molecular target in the striatum	SPECT radiotracers	PET radiotracers	Common indications
Presynaptic dopaminergic terminal
DAT	99mTc-TRODAT,123I-altropane,123I-beta-CIT,123I-FP-CIT (ioflupane)	18F-FP-CIT,11C-PE2I,18F-FE-PE2I	Evaluation of functional integrity of striatal dopaminergic neurons in patients with clinically uncertain parkinsonian syndromes
VMAT2		11C-DTBZ,18F-FP-DTBZ
AADC		18F-fluorodopa
Postsynaptic dopaminergic nerve
D2 receptors	123I-IBZM	11C-raclopride,18F-fallypride,18F-DMFP	Differential diagnosis of parkinsonian syndromes (PD vs. MSA, PSP and CBD)