Table 2.

Table 2. Drugs or other psychotropic substances that can significantly affect radiotracer binding in the DAT SPECT study [5–8, 23–26].

Drug class	Drug names	Potential effects
Cocaine	Cocaine	striatal 123I-ioflupane binding
Amphetamines	Amphetamine, methamphetamine, methylphenidate	striatal 123I-ioflupane binding
CNS stimulants	Phentermine, ephedrines	striatal 123I-ioflupane binding
Opioid derivatives	Fentanyl, modafinil	striatal 123I-ioflupane binding
Antidepressants	Bupropion, mazindol, radafaxine	striatal 123I-ioflupane binding
Adrenergic agonists	Norepinephrine, phenylephrine	striatal 123I-ioflupane binding. This effect occurs especially when infused at high doses
Anticholinergic drugs	Benztropine	striatal 123I-ioflupane binding. Other anticholinergic drugs striatal 123I-ioflupane binding to a degree that does not affect visual evaluation
Anesthetics	Isoflurane, ketamine, phencyclidine	striatal 123I-ioflupane binding