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. 2021 Feb 16;79(4):1813–1829. doi: 10.3233/JAD-200462

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© 2021 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — LCMT overexpression protects against electrophysiological impairments in Tg2576 mice. A) Time course of averaged Schaffer collateral fEPSP responses (±SEM) prior to and following delivery of theta-burst stimulation (arrow) in hippocampal slices prepared from 7-8-month-old mice that carried the Tg2576 APP transgene in combination with transgenic LCMT overexpression (LCMT + APP), or 7-8-month-old animals that carried the Tg2576 APP transgene alone (APP), overexpressed LCMT alone (LCMT), or controls. 2-way RM ANOVA for fEPSP responses over the last 20 min of recording with group and time as factors shows a significant effect of group (horizontal bar; F(3, 60) = 5.297, p = 0.0026). Dunnett’s multiple comparisons show that the APP group was significantly different from each of the other three groups (p = 0.0481 for LCMT + APP, p = 0.0033 for LCMT and p = 0.0019 for control). N = 14 control, 13 APP, 18 LCMT, 19 LCMT + APP. Representative traces of field potential responses prior to TBS, and during the last 20 min of recording are shown above for each of the indicated genotypes. B) Time course of averaged Schaffer collateral fEPSP responses (±SEM) prior to and following delivery of theta-burst stimulation (arrow) in hippocampal slices prepared from 10-11-month-old mice that carried the Tg2576 APP transgene in combination with transgenic LCMT overexpression (LCMT + APP), or 10-11-month-old animals that carried the Tg2576 APP transgene alone (APP), overexpressed LCMT alone (LCMT), or controls. 2-way RM ANOVA for fEPSP responses over the last 20 min of recording with group and time as factors shows a significant effect of group (horizontal bar; F(3, 43) = 7.328, p = 0.0004). Dunnett’s multiple comparisons show that the APP group was significantly different from each of the other three groups (p = 0.0003 for LCMT + APP, p = 0.0183 for LCMT and p = 0.0013 for control). N = 11 control, 12 APP, 12 LCMT, 12 LCMT + APP. Representative traces of field potential responses prior to TBS, and during the last 20 min of recording are shown above for each of the indicated genotypes.