Table 3.
Linear regression estimates (unadjusted and adjusted) for the association between various measures and levels of CSF C18 ceramide
| CSF C18 ceramide (A.U.)a | ||||||
| Unadjusted model | Adjusted model* | |||||
| St. β | p | St. β | p | |||
| Demographics | ||||||
| Age, y | –0.02 | 0.902 | –0.05 | 0.765 | ||
| Education, y | –0.05 | 0.688 | –0.07 | 0.596 | ||
| CSF proteinsa | ||||||
| Aβ42 (pg/ml) | –0.35 | 0.006 | –0.36 | 0.007 | ||
| T-tau (pg/ml) | 0.30 | 0.018 | 0.41 | 0.005 | ||
| P-tau (pg/ml) | 0.17 | 0.188 | 0.21 | 0.129 | ||
| T-tau/Aβ42 | 0.44 | < 0.001 | 0.52 | < 0.001 | ||
| NFL (ng/ml) | 0.03 | 0.835 | 0.05 | 0.782 | ||
| YKL-40 (ng/ml) | 0.11 | 0.411 | 0.25 | 0.194 | ||
| S100B (pg/ml) | 0.37 | 0.004 | 0.51 | 0.001 | ||
| GFAP (ng/ml) | 0.22 | 0.087 | 0.26 | 0.087 | ||
| Verbal episodic memory | ||||||
| RAVLT immediate recall, scoreb | –0.02 | 0.893 | –0.01 | 0.928 | ||
| RAVLT delayed recall, scoreb | –0.18 | 0.339 | –0.29 | 0.095 | ||
| Story immediate recall, score | –0.13 | 0.356 | –0.14 | 0.345 | ||
| Story delayed recall, score | –0.13 | 0.305 | –0.15 | 0.335 | ||
A.U., arbitrary units; RAVLT, Rey Auditory Verbal Learning Test. Numbers present standardized beta coefficients (st.β). *Adjusted for age, gender, and years of education. aValues log2-transformed and autoscaled before analysis. bAnalysis based on 59 subjects, with one missing.