Table 3.
Univariate and Multivariate Analyses of Prognostic Factors for OS in the Validation Cohort
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age (>/≤50 years) | 0.92 | 0.68–1.26 | 0.614 | |||
| Sex (male/female) | 0.98 | 0.61–1.58 | 0.943 | |||
| Aetiology (HBV/non-HBV) | 0.84 | 0.66–1.66 | 0.839 | |||
| WBC (>/≤11*109/L) | 0.52 | 0.13–2.08 | 0.352 | |||
| PLT (>/≤100*109/L) | 1.80 | 0.98–3.33 | 0.059 | |||
| TBIL (>/≤17 mmol/L) | 1.26 | 0.91–1.75 | 0.169 | |||
| ALB (>/≤35 g/L) | 1.58 | 0.74–3.37 | 0.237 | |||
| CRP (>/≤10 mg/L) | 2.02 | 1.46–2.79 | <0.001 | |||
| AFP (>/≤200 ng/mL) | 1.96 | 1.44–2.68 | <0.001 | 1.72 | 1.25–2.37 | 0.001 |
| ALBI score (I/II–III) | 1.52 | 1.10–2.10 | 0.012 | |||
| Tumour size (>/≤5 cm) | 2.57 | 1.85–3.59 | <0.001 | 1.56 | 1.06–2.28 | 0.023 |
| Tumour number (>/≤1) | 1.72 | 1.21–2.44 | 0.002 | |||
| Macrovascular invasion (yes/no) | 3.14 | 2.14–4.61 | <0.001 | |||
| Treatment (resection/RFA) | 1.34 | 0.95–1.90 | 0.099 | |||
| TNM stage (I/II–III/IV) | 2.95 | 2.13–4.08 | <0.001 | 1.98 | 1.39–2.82 | <0.001 |
| GPS | ||||||
| 0 | ||||||
| 1 | 0.63 | 0.23–1.71 | 0.364 | |||
| 2 | 1.34 | 0.48–3.69 | 0.577 | |||
| Modified GPS | ||||||
| 0 | ||||||
| 1 | 0.64 | 0.24–1.74 | 0.381 | |||
| 2 | 1.32 | 0.48–3.66 | 0.590 | |||
| NLR (0/1) | 1.46 | 0.72–2.96 | 0.300 | |||
| PLR | ||||||
| 0 | ||||||
| 1 | 0.48 | 0.07–3.40 | 0.458 | |||
| 2 | 0.83 | 0.11–6.03 | 0.851 | |||
| PI (0/1/2) | ||||||
| 0 | ||||||
| 1 | 2.18 | 0.30–15.60 | 0.439 | |||
| 2 | 4.59 | 0.64–33.20 | 0.131 | |||
| PNI (0/1) | 1.30 | 0.82–2.05 | 0.263 | |||
| LCR (0/1) | 2.37 | 1.73–3.25 | <0.001 | 1.89 | 1.34–2.67 | <0.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval; HBV, hepatitis B virus; WBC, white blood cell; TBIL, total bilirubin; ALB, albumin; CRP, C-reactive protein; AFP, α-fetoprotein; ALBI score, albumin–bilirubin score; TNM, tumour-node-metastasis; RFA, radiofrequency ablation; GPS, Glasgow prognostic score; mGPS, modified Glasgow prognostic score; NLR, neutrophil-lymphocyte ratio; PLR, platelet-lymphocyte ratio; PI, prognostic index; PNI, prognostic nutritional index; LCR, lymphocyte-C-reactive protein ratio.