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. 2021 Jun 10;13:4647–4655. doi: 10.2147/CMAR.S311061

Table 2.

Univariate and Multivariate Analysis of Overall Survival in Patients with GBC

Univariate Analysis Multivariate Analysis
Variables HR 95% CI P HR 95% CI P
Age, years (>62 versusInline graphic62) 0.871 0.664–1.141 0.316
Gender (female versus male) 0.911 0.686–1.209 0.518
Cholelithiasis (absent versus present) 1.213 0.925–1.590 0.163
TB, umol/L (>12.4 versus Inline graphic12.4) 1.037 0.792–1.359 0.790
ALT, IU/L (>23 versus Inline graphic23) 1.066 0.813–1.397 0.645
AST, IU/L (>24 versus Inline graphic24) 1.242 0.948–1.628 0.115
ALB, g/L (>41.0 versus Inline graphic41.0) 0.775 0.589–1.018 0.067
WBC, Inline graphic109/L (>6.13 versus Inline graphic.13) 1.233 0.940–1.617 0.130
PLT,Inline graphic109/L (>205 versus Inline graphic205) 1.106 0.845–1.448 0.463
PDW (>14.95 versus Inline graphic14.95) 1.796 1.357–2.376 <0.001 1.976 1.474–2.650 <0.001
NLR (>2.74 versus Inline graphic2.74) 1.576 1.199–2.070 0.001 1.157 0.869–1.542 0.317
PLR (>136.84 versus Inline graphic136.84) 2.229 1.680–2.957 <0.001 1.894 1.406–2.550 <0.001
PNI (>46.8 versus Inline graphic46.8) 0.922 0.701–1.212 0.559
CA19-9, U/mL (>23.23 versus Inline graphic23.23) 1.736 1.318–2.285 <0.001 1.283 0.949–1.735 0.106
CEA, U/mL (>2.81 versus Inline graphic2.81) 1.286 0.982–1.684 0.068
Pre-operative biliary drainage (absent versus present) 1.315 0.864–2.000 0.201
IGBC (absent versus present) 0.302 0.211–0.431 <0.001 0.370 0.250–0.547 <0.001
Vascular invasion (absent versus present) 1.704 1.220–2.381 0.002 1.302 0.914–1.854 0.144
Perineural invasion (absent versus present) 1.515 1.092–2.102 0.013 1.132 0.804–1.595 0.478
Tumor differentiation (well/moderate versus poor) 1.626 1.235–2.141 0.001 1.344 1.010–1.790 0.043
T stage (T1/2 versus T3/4) 3.576 2.602–4.915 <0.001 1.496 1.024–2.185 0.037
N stage (N0 versus N1/2) 3.400 2.502–4.620 <0.001 2.034 1.440–2.873 <0.001
Margin status (R0 versus R1) 2.497 1.786–3.492 <0.001 1.753 1.241–2.477 0.001
Postoperative adjuvant therapy (yes versus no) 1.194 0.877–1.626 0.259

Abbreviations: GBC, gallbladder carcinoma; HR, hazard ratio; CI, confidence interval; TB, total bilirubin; ALT, alanine aminotransferase; AST, aspartate transaminase; ALB, albumin; WBC, white blood cell count; PLT, platelet; PDW, platelet distribution width; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index; CA 19–9, carbohydrate antigen 19–9; CEA, carcinoembryonic antigen; AJCC, American Joint Committee on Cancer.