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. 2021 Jun 9;10:e58688. doi: 10.7554/eLife.58688

Figure 1. Macroscopic and microscopic characterization of EGI-1, KPC, MMTV-PyMT, mPDAC, and MET-1 tumor models.

Figure 1.

(A) Tumor volume and tumor mean stiffness relationship. Tumor volume was measured using a caliper or ultrasound, whilst tumor mean stiffness was measured using SWE. (B) The percentage of stiff regions in relation to tumor volume. The presence of very stiff regions with an elastic modulus > 40 kPa was quantified using data from the stiffness map extracted from the SWE images. (C) Comparison of the histological diversity within the tumor models. Representative images of each tumor model (scale bar = 100 µm). (D) SHG images of the collagen network in each of the models at the end point of the experiment. Scale bar = 20 µm. EGI-1 (n = 30 mice from three independent experiments); KPC (n = 34 mice from three independent experiments); MMTV-PyMT (n = 5 mice, 10 tumors per mouse from two independent experiments); mPDAC (n = 7 mice from two independent experiments); and MET-1 (n = 12 mice from two independent experiments).

Figure 1—source data 1. Source data file for Figure 1.