TABLE 4.
Top nine differentially methylated sites of the differential aging-related genes associated with asthma.
| CpG site | Gene | AUC | p-value | Optimal diagnostic threshold | Sensitivity | Specificity |
|---|---|---|---|---|---|---|
| Chr4:75310649-1 | AREG | 0.716 | 0.009 * | 0.086 | 0.724 | 0.81 |
| Chr20:32274088 | E2F1 | 0.717 | 0.009 * | 0.009 | 0.517 | 0.857 |
| Chr20:32274358 | E2F1 | 0.746 | 0.022 * | 0.043 | 1 | 0.533 |
| Chr6:108883024 | FOXO3 | 0.653 | 0.066 | 0.166 | 0.909 | 0.667 |
| Chr6:108882977 | FOXO3 | 0.671 | 0.040 * | 0.263 | 0.69 | 0.714 |
| Chr16:55514392 | MMP2 | 0.763 | 0.038 * | 0.038 | 0.69 | 0.614 |
| Chr16:55514437 | MMP2 | 0.688 | 0.024 * | 0.017 | 0.414 | 1 |
| Chr1:163291825 | NUF2 | 0.708 | 0.010 * | 0.012 | 0.862 | 0.571 |
| Chr17:7591672 | TP53 | 0.721 | 0.008 * | 0.015 | 0.966 | 0.476 |
Statistics were done by SPSS 22.0.
*
p-value < 0.05 was considered statistically significant.