TABLE 2.
Some agents target Wnt/β-catenin pathway in colon cancer.
| Agents | Regulation | Reference |
|---|---|---|
| Retinoic acid | Inhibit Wnt signaling by direct interaction with β-catenin/competition for TCF binding | Roa et al. (2019) |
| Vitamin D | Encourages the β-catenin binding to the vitamin D receptor and decreases the amount of β-catenin | Roa et al. (2019) |
| Quercetin | Suppresses Wnt inhibiting activity | Roa et al. (2019) |
| Resveratrol | Suppresses Wnt inhibiting activity | Roa et al. (2019) |
| Green tea polyphenol epigallocathechin-3-gallate | Suppresses Wnt inhibiting activity | Roa et al. (2019) |
| LGK974 | Binds and blocks the porcupine enzyme | Liu et al. (2013) |
| PRI-724 | Increase p300/β-catenin binding and stem-cell differentiation | Lenz and Kahn (2014) |
| BBI608 | Not only inhibits signal transducer and activator of Stat3 but also suppresses β-catenin signaling | Ciombor et al. (2015) |