TABLE 4.

MicroRNAs regulate PI3K/AKT/mTOR pathway in liver cancer.

miRNA	Regulation	Pathway	References
miR-758-3P	Down-regulated the expression of MDM2 and mTOR/Upregulated the expression of p53, AKT and PRAS40	PI3K/AKT/mTOR pathway	Jiang et al. (2017)
miR-187	Leads to a significant halt in the growth of HCC.	PI3K/AKT/mTOR pathway	Han et al. (2017)
miR-497	Target the 3′-UTR of IGF-1R and mTOR, decrease tumor proliferation and tumor growth	PI3K/AKT/mTOR pathway	Cheng et al. (2017)
miR-99a	Target the 3′-UTR of IGF-1R and mTOR, decrease tumor proliferation and tumor growth	PI3K/AKT/mTOR pathway	Han et al. (2017)
miR-592	Down-regulated in HCC tissues and cell lines, and was associated with lymph node metastasis	PI3K/AKT/mTOR pathway	Wang et al. (2017)
miR2965p	Inhibited HCC cell proliferation, migration and invasion in vitro by targeting AKT2	PI3K/AKT/mTOR pathway	Yu et al. (2017)
miR-142	Controls cell vitality, proliferation, (EMT) and neo-angiogenesis target TGF-β	PI3K/AKT/mTOR pathway	Yu et al. (2017)
miR-23b	As a suppressor of the AKT/GSK3β/β-catenin pathway in HCC cells by regulating ST7L	PI3K/AKT/mTOR pathway	Jiang et al. (2017)
miR-181A	Plays a carcinogenic role targeting PTEN	PI3K/AKT/mTOR pathway	Han et al. (2017)
miR-155-5p	Plays a carcinogenic role targeting PTEN	PI3K/AKT/mTOR pathway	Cheng et al. (2017)
miR-25	Plays a carcinogenic role targeting PTEN	PI3K/AKT/mTOR pathway	Wang et al. (2017)