Table 2.
Univariate and multivariate analysis of disease-free survival in HCC patients.
| Clinicopathologic parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (<60 vs. ≥60) | 0.637 (0.371-1.093) | 0.102 | ||
| Gender (female vs. male) | 1.506 (0.647-3.506) | 0.342 | ||
| Hepatitis B (negative vs. positive) | 1.729 (0.785-3.810) | 0.174 | ||
| AFP (<400 vs. ≥400) | 1.355 (0.808-2.273) | 0.249 | ||
| Cirrhosis (present vs. absent) | 1.302 (0.764-2.221) | 0.332 | ||
| Microvascular invasion (present vs. absent) | 0.931 (0.337-2.573) | 0.891 | ||
| Tumor differentiation (low vs. high/moderate) | 1.018 (0.611-1.698) | 0.944 | ||
| Capsular invasion (present vs. absent) | 1.575 (0.939-2.644) | 0.085 | 1.272 (0.753-2.147) | 0.369 |
| TNM stage (I~II vs. III~IV) | 2.008 (1.190-3.386) | 0.009 | 1.094 (0.550-2.175) | 0.798 |
| Tumor diameter (<5 cm vs. ≥5 cm) | 1.875 (1.010-3.482) | 0.046 | 1.861 (0.969-3.571) | 0.062 |
| Multiple lesions (present vs. absent) | 2.481 (1.392-4.419) | 0.002 | 2.229 (1.245-3.993) | 0.007∗ |
| Vessel carcinoma embolus (present vs. absent) | 2.250 (1.260-4.019) | 0.006 | 2.195 (1.169-4.120) | 0.014∗ |
| SNORA52 expression (low vs. high) | 0.374 (0.220-0.634) | <0.001 | 0.481 (0.277-0.836) | 0.009∗ |
AFP: α-fetoprotein; TNM: tumor-node-metastasis; ∗P < 0.05 was considered to be statistically significant.