. 2021 Jun 15;3(10):2154–2166. doi: 10.1007/s42399-021-00940-1

Table 2.

Typical and atypical CSD manifestations

Immunocompromised patient	Immunocompetent patient
1. Bacillary angiomatosis (cutaneous lesions resemble Kaposi’s sarcoma) 2. Systemic CSD (multiorgan involvement with rash) 3. Peliosis hepatis (dilated, blood cysts in the liver and spleen)	Typical CSD (90–95% of cases): subacute regional lymphadenitis preceded by cutaneous inoculation ATYPICAL CSD 1. CNS: seizure, headache, altered mental status, frequently encephalitis 2. Hepatosplenic: multiple low density lesions on abdominal imaging 3. Cardiac: mitral and aortic valve vegetations multiple, rapidly progressive 4. Parinaud’s: conjunctivitis and regional preauricular lymphadenitis 5. MSK: Myalgia, arthropathy, osteomyelitis, and tendinitis

Immunocompromised patient

Immunocompetent patient

1. Bacillary angiomatosis (cutaneous lesions resemble Kaposi’s sarcoma)

2. Systemic CSD (multiorgan involvement with rash)

3. Peliosis hepatis (dilated, blood cysts in the liver and spleen)

Typical CSD (90–95% of cases): subacute regional lymphadenitis preceded by cutaneous inoculation

ATYPICAL CSD

1. CNS: seizure, headache, altered mental status, frequently encephalitis

2. Hepatosplenic: multiple low density lesions on abdominal imaging

3. Cardiac: mitral and aortic valve vegetations multiple, rapidly progressive

4. Parinaud’s: conjunctivitis and regional preauricular lymphadenitis

5. MSK: Myalgia, arthropathy, osteomyelitis, and tendinitis