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. 2021 Jun 15;131(12):e146788. doi: 10.1172/JCI146788

Figure 4. Impaired first-phase insulin secretion, rather than reduced β cell mass, predicts diabetes appearance.

Figure 4

Clamp-derived first-phase insulin secretion (A), second-phase insulin secretion (B), and arginine-stimulated insulin secretion (C) before and after partial pancreatectomy in post-NGT (green box), post-IGT (orange box), and post-DM subjects (red box). INC, incremental. The relationship between variables was derived by linear regression analysis. Variables were regressed against glucose tolerance status by using (a) prepancreatectomy values, (b) postpancreatectomy values, and (c) postpancreatectomy values adjusted for prepancreatectomy values. *P < 0.05 before surgery; #P < 0.05 after surgery; §P < 0.05 before surgery adjusted for after surgery. Box plots indicate median and interquartile range, and whiskers indicate 2.5th–97.5th percentile ± mean value.