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. 2021 Jun 15;131(12):e146353. doi: 10.1172/JCI146353

Figure 2. Chronic treatment with tirzepatide ameliorates insulin resistance in mice.

Figure 2

Obese insulin-resistant mice were dosed once daily for 14 days with vehicle or tirzepatide (TZP, 10 nmol/kg; n = 13–15 per group). Following 14 days of treatment, insulin sensitivity was assessed via a hyperinsulinemic-euglycemic clamp. (A) Average glucose infusion rates (GIR) throughout and GIR during the final 30 minutes of the clamp. (B) Endogenous glucose production (EGP). Insulin-stimulated glucose disposal in (C) white gastrocnemius, (D) red gastrocnemius, (E) soleus skeletal muscle, (F) epididymal (eWAT), and (G) inguinal (iWAT) white adipose tissue. Data are presented as mean ± SEM. *P < 0.05 compared with vehicle. Statistical analyses performed included Kruskal-Wallis test followed by Bonferroni multiple comparisons test, where appropriate.