Skip to main content
. 2021 Jun 15;131(12):e146353. doi: 10.1172/JCI146353

Figure 7. Tirzepatide and GIPR agonism induced BCAA catabolic gene expression in BAT in obese IR mice.

Figure 7

High-fat diet–fed obese insulin-resistant mice (C57BL/6J) were dosed once daily with vehicle (saline, n = 6), tirzepatide (TZP, n = 6), a long-acting glucose-dependent insulinotropic polypeptide receptor agonist (LAGIPRA, n = 6), or saline (pair fed, n = 6). Following 14 days of treatment, tissue samples were collected for metabolic and molecular analyses. (A) Venn diagram of differentially (up- and downregulated gene expression) expressed genes (FDR < 0.05). (B) Heatmap of RNA-Seq expression Z-scores computed for genes associated with the branched-chain amino acid (BCAA) pathway in brown adipose tissue (BAT). *P < 0.05 compared with vehicle and #P < 0.05 compared with pair fed. Statistical analyses was performed using 1-way ANOVA, followed by FDR correction, where appropriate.