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. 2021 Jun 15;131(12):e139202. doi: 10.1172/JCI139202

Figure 1. Peripheral ischemia in patients with sickle cell disease is not sufficient to promote the development of NV.

Figure 1

(A) Retinal ischemic index in all patients with sickle cell disease without PSR (no PSR) and with PSR (PSR). Blue and red dotted lines identify mean retinal ischemic index in patients with and without PSR, respectively. (B) Retinal ischemic index in patients with sickle cell disease divided by hemoglobin status (SS, SC, and Sβthal) without (–) and with (+) PSR. Blue arrows identify patients without PSR with a retinal ischemic index greater than the average for patients with PSR. Red arrows identify patients with PSR with retinal ischemic index less than the average for patients without PSR. The ischemic indices of patients without PSR and with PSR were compared using a 2-tailed Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.