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. 2021 Jun 15;131(12):e145859. doi: 10.1172/JCI145859

Figure 2. Human melanoma dedifferentiation is induced by exposure to IFN-γ.

Figure 2

(A) Flow cytometric data for MART-1 and NGFR in the human melanoma cell lines M262 (baseline differentiated) and M370 (baseline undifferentiated) in response to TNF or IFN-γ exposure. (B) Projection of cytokine-treated cell lines onto melanoma M series differentiation PCA (6). Diff, baseline differentiated; undiff, baseline undifferentiated. (C) Expression of melanoma differentiation genes for 0 hour, IFN-γ, and TNF across cell lines. U, undifferentiated at baseline, U-NC, undifferentiated neural crest–like, NC, neural crest–like, NC-T, neural crest–like transitory, T, transitory, T-M, transitory melanocytic, M, melanocytic. Colors represent z scores. (D) Common melanoma mutations across cell line studies. Nonsense or missense JAK/STAT mutations were not observed.